G-protein coupled receptors, also known as G-protein linked receptors and seven-transmembrane domain receptors are a large family of cell surface receptors that bind molecules outside the cell and initiate the signaling inside the cell that can result in a multitude of effects, including gene expression, membrane trafficking and cell cycle progression. Several G protein coupled receptors are involved in the immune system and are expressed on cells such as leukocytes.
The molecules that bind these receptors include hormones, pheromones and neurotransmitters. A number of G-protein coupled receptors signal cellular events via the transcription factor CREB.
G-protein coupled receptors are involved in many diseases and are also the target of approximately 40% of all medicinal drugs.
Major Classes of G Protein Coupled Receptors
- Class A Rhodopsin-like
- Class B Secretin Receptor
- Class C Metabotrophic glutamate
- Class D Fungal Mating Pheromone Receptors
- Class E cyclicAMP receptors
- Class F Frizzled/Smoothened
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Introduction to Receptors
- G Protein Coupled Receptors
- Receptor Tyrosine Kinase
- Toll-like Receptors
- Ligand-Gated Ion Channels
- The Basics of Cell Surface Receptors
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