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G-Protein Coupled Receptors

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The G Protein Coupled Receptors (GCPR) are commonly known as seven-transmembrane receptors. These g-protein coupled receptors are located in the cell membrane and belong to a large group of cell surface receptors that include 7TM, heptahelical, serpentine, and G protein-linked receptors (GPLR).

6 Major classes of these:

  • Class A (or 1) (Rhodopsin-like)

  • Class B (or 2) (Secretin receptor family)

  • Class C (or 3) (Metabotropic glutamate/pheromone)

  • Class D (or 4) (Fungal mating pheromone receptors)

  • Class E (or 5) (Cyclic AMP receptors)

  • Class F (or 6) (Frizzled/Smoothened)

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